The Biology of the TGF-ß Family
Edited by Rik Derynck, University of California, San Francisco; Kohei Miyazono, University of Tokyo
©2017 • 1,164 pp., illus., index • ISBN 978-1-621820-36-9



Cold Spring Harbor Monograph #50

The TGF-ß Family
edited by Rik Derynck and Kohei Miyazono
©2008 • 1,114 pp., illus., index • ISBN 978-087969752-5



257) DERYNCK, R. and WEINBERG, R.A. (2019) EMT and cancer: more than meets the eye. Developmental Cell 49, 313-316. [PubMed]

256) DUAN, D. and DERYNCK, R. (2019) Ligand-induced upregulation of the TGF-b receptors at the cell surface amplifies the TGF-b response. J. Biol. Chem. 294, 8490-8504.  [PubMed]

255) DERYNCK, R. and BUDI, E.H. (2019) Specificity, versatility and control of TGF-b family signaling. Science Signaling 12, eaav5183.  [PubMed]

254) KATSUNO, Y., MEYER, D., ZHANG, Z., SHOKAT, K.M., AKHURST, R.J., MIYAZONO, K., and DERYNCK, R. (2019) Chronic TGF-β exposure drives stabilized EMT, tumor stemness and cancer drug resistance with vulnerability to bitopic mTOR inhibition. Science Signaling 12, eaau8544.   [PubMed]

253) BUDI, E.H., MAMAI, O., HOFFMAN, S., AKHURST, R., and DERYNCK, R. (2019) Enhanced TGF-b signaling contributes to the insulin-induced angiogenic responses of endothelial cells. iScience 11, 474-491.  [PubMed]

252) KATSUNO, Y., QIN, J., OSES-PRIETO, J., WANG, H., JACKSON-WEAVER, O., ZHANG, T., LAMOUILLE, S., WU, J., BURLINGAME, A., XU, J., and DERYNCK, R. (2018) Arginine methylation of Smad7 by PRMT1 in TGF-β-induced epithelial-mesenchymal transition and epithelial stem-cell generation. J. Biol. Chem. 293, 13059-13072.  [PubMed]

251) DU, D., KATSUNO, Y., MEYER, D., BUDI, E.H., KOEPPEN, H., AKHURST, R.J., and DERYNCK, R. (2018) Smad3-mediated recruitment of the methyltransferase SETDB1/ESET controls Snail1 expression and epithelial-mesenchymal transition. EMBO Reports 19, 135-155.   [PubMed]

250) WEI, Y., KIM, T.J., PENG, D.J., DUAN, D., GIBBONS, D.L., YAMAUCHI, M., JACKSON, J.R., LE SAUX, C.J., CALHOUN, C., PETERS, J., DERYNCK, R, BACKES, B.J., and CHAPMAN, H.A. (2017) Fibroblast-specific inhibition of TGF-b1 signaling inhibits lung and tumor fibrosis by. J. Clin. Invest. 127, 3675-3688.  [PubMed]

249) BUDI, E., DUAN, D. and DERYNCK, R. (2017) TGF-b receptors and Smads: regulatory complexity and functional versatility. Trends Cell Biol 27, 658-672.   [PubMed]

248) KIME, C., SAKAKI-YUMOTO, M., GOODRICH, L., HAYAHASHI, Y., SAMI, S., DERYNCK, R., ASAHI, M., PANNING, B., YAMANAKA, S., and TOMODA, K. (2016) Autotaxin‐mediated lysophosphatidic acid signaling intersects with LIF and BMP signaling to promote the naive pluripotency transcription factor program. Proc. Natl. Acad. Sci. USA 113, 12478-12483.  [PubMed]

247) MOSES, H.L., ROBERTS, A.B., and DERYNCK, R. (2016) The discovery and early days of TGF-b: a historical perspective. Cold Spring Harbor Perspectives in Biology 8, a021865. Also in “The Biology of the TGF-b Family” (R. Derynck and K. Miyazono, eds), Cold Spring Harbor Press 2017. Chapter 1, pp 1-26.   [PubMed]

246) MORIKAWA, M., DERYNCK, R. and MIYAZONO, K. (2016) TGF-β and the TGF-β family: context-dependent roles in cell and tissue physiology. Cold Spring Harbor Perspectives in Biology 8, a021873. In “The biology of the TGF-b Family” (R. Derynck and K. Miyazono, eds), Cold Spring Harbor Press 2017. Chapter 1, pp 27-50.  [PubMed]

245)  BUDI, E.H., XU, J. and DERYNCK, R. (2016) Regulation of TGF-b receptors. TGF-b Signaling: Methods and Protocols (Feng, X.-H. et al. editors), Methods in Molecular Biology 1344, 1-33.  [PubMed]

244) MUTHUSAMY, B.P., BUDI, E.H., KATSUNO, Y., LEE, M.K., SMITH, S.M., MIRZA, A.M, AKHURST, R. and DERYNCK, R. (2015) ShcA protects against epithelial-mesenchymal transition through compartmentalized inhibition of TGF-b-induced Smad activation. PLoS Biology 13, e1002325. [PubMed]

243) BUDI, E.H., MUTHUSAMY, B.P., and DERYNCK, R. (2015) The insulin response integrates increased TGF-b signaling through Akt-induced enhancement of cell surface delivery of TGF-b receptors. Science Signaling 8, ra96, 1-15. [PubMed]

242) XU, P., BAILEY-BUCKTROUT, S., XI, J., XU, D., DU, D., ZHANG, Q., XIANG, W., LIU, J., MELTON, A., SHEPPARD, D., CHAPMAN, H.A., BLUESTONE, J. E. and DERYNCK, R. (2014) Innate antiviral host defense attenuates TGF-b function through IRF3-mediated suppression of Smad signaling. Molecular Cell 56, 723-737. (highlighted in a preview by Zhu, Li and Flavell. 2014. Resemble and inhibit: when RLR meets TGF-b. Molecular Cell 56, 719-720). [PubMed]

241) XU, J. and DERYNCK, R. (2014) Does Smad6 methylation control BMP signaling in cancer? Cell Cycle 13, 1209-1210. [PubMed]

240) DERYNCK, R., MUTHUSAMY, B.P., and SAETEURN, K.Y. (2014) Signaling pathway cooperation in TGF-b-induced epithelial-mesenchymal transition. Current Opinion in Cell Biology 31, 56-66. [PubMed]

239) LAMOUILLE, S., XU, J., and DERYNCK, R. (2014) Molecular mechanisms of epithelial-mesenchymal transition. Nature Reviews in Molecular and Cell Biology 15, 178-196. [PubMed]

238) DERYNCK, R. and AKHURST, R.J. (2013) BMP-9 balances endothelial cell fate. Proc. Natl. Acad. Sci. USA110, 18746-18747. [PubMed]

237) XU, J., WANG, H.A., OSES-PRIETO, J., MAKHIJANI, K., KATSUNO, Y., PEI, M., YAN, L., ZHENG, Y. G., BURLINGAME, A., BRÜCKNER, and DERYNCK, R. (2013) Arginine methylation initiates BMP-induced Smad signaling. Molecular Cell 51, 5-19. (highlighted in a Preview by Guo, X. and Wang, X-F. 2013. A P(E)RM(I)T for BMP signaling. Molecular Cell 51, 1-2) [PubMed]

236) SAKAKI-YUMOTO, M., LIU, J., RAMALHO-SANTOS, M., YOSHIDA, N. and DERYNCK, R. (2013) Smad2 is essential for maintenance of the human and mouse primed pluripotent stem cell state. J. Biol. Chem. 288, 18546-18560. [PubMed]

235) LAMOUILLE, S., SUBRAMANYAM, D., BLELLOCH, R. and DERYNCK, R. (2013) Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs. Current Opinion in Cell Biology 25, 200-207. [PubMed]

234) SAKAKI-YUMOTO, M., KATSUNO, Y., and DERYNCK, R. (2013) TGF-b family signaling in stem cells.  Biochimica Biophysica Acta 1830, 2280-2296. Review [PubMed]

233) KATSUNO, Y., LAMOUILLE, S., and DERYNCK, R. (2013) TGF-b signaling and epithelial-mesenchymal transition in cancer progression. Current Opinion in Oncology 25, 76-84. Review [PubMed]

232) XU, P., LIU, J., and DERYNCK, R. (2012) Post-translational regulation of TGF-b receptor and Smad signaling. FEBS Letters 586, 1871-1884. Review [PubMed]

231) XU, P., LIU, J., SAKAKI-YUMOTO, M., and DERYNCK, R.  (2012) TACE activation by MAPK-mediated regulation of cell surface dimerization and TIMP3 association. Science Signaling 5, ra34. [PubMed]

230) LAMOUILLE, S., CONNOLLY, E., SMYTH, J. W., AKHURST, R.J. and DERYNCK, R.  (2012) TGF-b-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and invasion.  J. Cell Science 125, 1259-1273. [PubMed]

229) UPADHYAY, G., YIN, Y., YUAN, H., LI, X., DERYNCK, R., and GLAZER, R.I. (2011) Stem cell antigen-1 modulates tumorigenicity by disruption of growth and differentiation factor-10 (GDF10)-dependent TGF-β signaling. Proc. Natl. Acad. Sci. USA 108, 7820-7825. [ PubMed ] [ PDF ]

228) SUBRAMANYAM, D., LAMOUILLE, S., JUDSON, R.L., LIU, J. Y., BUCAY, N., DERYNCK, R., and BLELLOCH, R. (2011) Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nature Biotechnology 29, 443-448. [ PubMed ] [ PDF ]

227) LAMOUILLE, S. and DERYNCK, R. (2011) Emergence of the PI3 kinase-Akt-mTOR axis in TGF-β-induced epithelial-mesenchymal transition. Cells Tissues and Organs 193, 8-22. [ PubMed ] [ PDF ]

226) CHANG, J. L., BRAUER, D.S., JOHNSON, J., CHEN, C., AKIL, O., BALOOCH, G., HUMPHREY, M.B., CHIN, E.N., POTTER, A., BUTCHER, K., RITCHIE, R., SCHNEIDER, R.A., LALWANI, A., DERYNCK, R., MARSHALL, G.W., MARSHALL, S.J., LUSTIG, L. and ALLISTON, T. (2010) Tissue-specific tuning of extracellular matrix material properties by TGF-β and Runx2 is required for hearing. EMBO Reports 11, 765-771. [ PubMed ] [ PDF ]

225) XU, P. and DERYNCK, R. (2010) Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation. Molecular Cell 37, 551-566. [ PubMed ] [ PDF ]

224) LAMOUILLE, S. and DERYNCK, R. (2009) Oncogene and tumor suppressor: the two faces of SnoN. EMBO J 28, 3458-3460. [ PubMed ] [ PDF ]

223) PISCOPO, D. M., JOHANSEN, E.B. and DERYNCK, R. (2009) Identification of the GATA factor TRPS1 as a repressor of the osteocalcin promoter. J. Biol. Chem., submitted 8/4/09, in press, 9/15/09 ref. JBC/2009/052316. [ PubMed ] [ PDF ]

222) WHARTON, K. and DERYNCK, R. (2009) TGF-β family signaling: novel insights in development and disease.Development 136, 3691-3697. [ PubMed ] [ PDF ]

221) KANG, J. S., LIU, C. and DERYNCK, R. (2009) New regulatory mechanisms of TGF-β receptor function.Trends in Cell Biology 19, 385-394. Review. [ PubMed ] [ PDF ]

220) WU, L., and DERYNCK, R. (2009) Essential role of TGF-β signaling in glucose-induced cell hypertrophy.Developmental Cell 17, 35-48. (subject of a Preview) [ PubMed ] [ PDF ]

219) LIU, C., XU, P. LAMOUILLE, S. XU, J. and DERYNCK R. (2009) TACE-mediated ectodomain shedding of the type I TGF-β receptor downregulates TGF-β signaling. Molecular Cell 35, 26-36. [ PubMed ] [ PDF ]

218) MOHAMMAD, K.S., CHEN, C., BALOOCH, G., STEBBINS, E., McKENNA, C.R., WALTON, H., NIEWOLNA, M., PENG, X.H., NGUYEN, D.H.N., IONOVA-MARTIN, S.S., BRACEY, J.W., HOGUE, W.R., WONG, D., RITCHIE, R.O., SUVA, L.J., DERYNCK, R., GUISE, T.A., and ALLISTON, T. (2009) Pharmacologic inhibition of the TGF-β type I receptor has anabolic and anti-catabolic effects. PLoS One, 4, e5275. [ PubMedCentral to PDF ] [ PDF ]

217) XU, J., LAMOUILLE, S. and DERYNCK, R. (2009) TGF-beta-induced epithelial to mesenchymal transition.Cell Research 19, 156-172. Review. [ PubMed ] [ PDF ]

216) LIU, I.M., SCHILLING, S.H., KNOUSE, K.A., CHOY, L., DERYNCK, R., and WANG, X.-F. (2009) TGF-beta-stimulated Smad1/5 phosphorylation functions as a pro-migratory TGF-beta switch in breast cancer cells. EMBO J. 28, 88-98. [ PubMed ] [ PDF ]

215) IMHOF, I., GASPER, W.J. and DERYNCK, R. (2008) Association of the tetraspanin CD9 with transmembrane TGF-alpha confers alterations in cell surface presentation of TGF-alpha and cytoskeletal organization. J. Cell Sci.121, 2265-2274. [ PubMed ] [ PDF ]

214) KANG, J.-S., SAUNIER, E., AKHURST, R.J. and DERYNCK, R. (2008) The type I TGF-beta receptor is covalently modified and regulated by sumoylation. Nature Cell Biology 10, 654-664. (subject of News and Views) [ PubMed ] [ PDF ]

213) ALLISTON, T., PIEK, E. and DERYNCK, R. (2008) TGF-beta family signaling in skeletal development, maintenance and disease. In The TGF-beta Family (R. Derynck and K. Miyazono, eds), Cold Spring Harbor Press, Chapter 22, 667-724. Review [ PDF ]

212) DERYNCK, R., PIEK, E., SCHNEIDER, R.A., CHOY, L. and ALLISTON, T. (2008) TGF-beta family signaling in mesenchymal differentiation. In The TGF-beta Family (R. Derynck and K. Miyazono, eds), Cold Spring Harbor Press, Chapter 21, 613-666. Review [ PDF ]

211) DERYNCK, R. and MIYAZONO, K. (2008) TGF-β and the TGF-β family. In “The TGF-β Family” (R. Derynck and K. Miyazono, eds), Cold Spring Harbor Press. Chapter 2, 29-44. Review. [ PDF ]

210) DERYNCK R, AKHURST RJ. (2007) Differentiation plasticity regulated by TGF-beta family proteins in development and disease. Nat Cell Biol. 9(9): 1000-4. [ PubMed ] [ PDF ]

209) LEE MK, PARDOUX C, HALL MC, LEE PS, WARBURTON D, QING J, SMITH SM, DERYNCK R. (2007) TGF-beta activates Erk MAP kinase signaling through direct phosphorylation of ShcA. EMBO J. 26(17):3957-67. [ PubMedCentral to PDF ] [ PDF ]

208) LAMOUILLE S, DERYNCK R. (2007) Cell size and invasion in TGF-beta induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J Cell Biol. 178(3):437-51. [ PubMedCentral to PDF ] [ PDF ]

207) PEREZ-CASTRO C, PISCOPO D, NAKAGAWA T, DERYNCK R. (2007) Cornichon regulates transport and secretion of TGF-alpha-related proteins in metazoan cells. J Cell Sci. 120(Pt 14): 2454-66. [ PubMed ] [ PDF ]

206) WAN DC, AALAMI OO, WANG Z, NACAMULI RP, LORGET F, DERYNCK R. (2006) Differential gene expression between juvenile and adult dura mater: a window into what genes play a role in the regeneration of membranous bone. Plast Reconstr Surg. 118(4):851-61. [ PubMed ] [ PDF ]

205) DERYNCK, R, CHOY, L., and ALLISTON, T. (2006) Smads in mesenchymal differentiation. In “Smad signal transduction” (ten Dijke, P. and Heldin, C.-H., eds), 93-112. Review. [ PDF ]

204) HABIG M, SMOLA H, DOLE VS, DERYNCK R, PFISTER H, SMOLA-HESS S. (2006) E7 proteins from high- and low-risk human papillomaviruses bind to TGF-beta-regulated Smad proteins and inhibit their transcriptional activity. Arch Virol. 151 (10): 1961-72. [ PubMed ] [ PDF ]

203) BALOOCH, G., BALOOCH, M., NALLA, R.K., SCHILLING, S., FILVAROFF, E.H., MARSHALL, G.W., MARSHALL, S.J., RITCHIE, R.O., DERYNCK, R., and ALLISTON, T. (2005) TGF-B signaling regulates the mechanical properties and composition of bone matrix. Proc. Natl. Acad. Sci. USA 102, 18813-18818. [ PubMedCentral to PDF ] [ PDF ]

202. MISHRA, L, DERYNCK, R. and MISHRA, B. (2005) Transforming growth factor-B signaling in stem cells and cancer. Science 310, 68-71. Review. [ PubMed ] [ PDF ]

201. FENG, X.-H. and DERYNCK, R. (2005) Specificity and versatility in TGF-B signaling through Smads. Annu. Rev. Cell Dev. Biol. 21, 659-693. Review. [ PubMed ] [ PDF ]

200. QIN, B., LIU, C., SRINATH, H., LAM, S.S., CORREIA, J.J., DERYNCK, R. and LIN, K. (2005) An activator-dependent conformational switch in CBP revealed by crystal structure of the IRF-3/CBP complex. Structure 13, 1269-1277. [ PubMed ] [ PDF ]

199. KANG, J. S., ALLISTON, T., DELSTON, R. and DERYNCK, R. (2005) Repression of Runx2 function by TGF-B through recruitment of class II histone deacetylases by Smad3. EMBO J. 24, 2543-2555. [ PubMed ] [ PDF ]

198. NAKAGAWA, T., GUICHARD, A., PEREZ CASTRO, C., XIAO, Y., RIZEN, M., ZHANG, H.-Z., HU, D., BANG, A., HELMS, J., BIER, E. and DERYNCK, R. (2005) Characterization of a human rhomboid homolog,p100hRho/RHBDF1, which interacts with TGF-A family ligands. Developmental Dynamics 233, 1315-1331. [ PubMed ] [ PDF ]

197. ALLISTON, T., KO, T.C., CAO, Y., LIANG, Y.-Y., FENG, X.-H., CHANG, C. and DERYNCK, R. (2005) Repression of BMP and activin-inducible transcription by Evi-1. J. Biol. Chem. 280, 24227-24237. [ PubMed ] [ PDF ]

196. PARDOUX, C. and DERYNCK, R. (2004) JNK regulates expression and autocrine signaling of TGF-bð1.Molecular Cell 15, 170-171. [ PubMed ] [ PDF ]

195. LIU, D., KANG, J.S. and DERYNCK, R. (2004) TGF-b-activated Smad3 represses MEF2-dependent transcription in myogenic differentiation. EMBO J. 23, 1557-1566. [ PubMedCentral to PDF ][ PDF ]

194. QING, J., LIU, C., CHOY, L., WU, R.-Y., PAGANO, J.S. and DERYNCK, R. (2004) TGF-b/Smad3 signaling regulates IRF-7 function and transcriptional activation of the interferon-b promoter. Molec. Cell. Biol. 24, 1411-1425. [ PubMedCentral to PDF ] [ PDF ]

193. QIN, B.Y., LIU, C., LAM, S.S., SRIMATH, H., DELSTON, R., CORREIA, J.J., DERYNCK, R. and LIN, K. (2003) Crystal structure of IRF-3 transactivation domain reveals mechanism of autoinhibition and virus-induced phospho-activation. Nature Struct. Biol. 10, 913-921. [ PubMed ] [ PDF ]

192. DERYNCK, R. and ZHANG, Y.E. (2003) Smad-dependent and Smad-independent pathways in TGF-b family signaling. Nature 425, 577-584. [ PubMed ]

191. LEE, P.S., CHANG, C., LIU, D. and DERYNCK, R (2003) Sumoylation of Smad4, the common Smad mediator of TGF-b family signaling. J. Biol. Chem. 278, 27853-27863. [ PubMed ]

190. FAN, H., TURCK, C.W. and DERYNCK, R. (2003) Characterization of growth factor-induced serine phosphorylation of tumor necrosis factor-a converting enzyme (TACE) and of an alternatively translated polypeptide. J. Biol. Chem. 278, 18617-18627. [ PubMed ]

189. CHOY, L. and DERYNCK, R. (2003) TGF-b inhibits adipocyte differentiation by Smad3 interacting with CCAAT/Enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function. J. Biol. Chem. 278, 9609-9619. [ PubMed ]

188. SKILLINGTON, J., CHOY, L., and DERYNCK, R. (2002) Bone morphogenetic protein and retinoic acid signaling cooperate to induce osteoblast differentiation of pre-adipocytes. J. Cell Biol. 159: 135-146. [ PubMedCentral to PDF ]

187. LI, C., ZHU, N.L., TAN, R.C., BALLARD, P.L., DERYNCK, R., and MINOO, P. (2002) TGF-b inhibits pulmonary surfactant protein-B gene transcription through SMAD3 interactions with NKX2.1 and HNF-3 transcription factors. J Biol Chem. 277, 38399-38408. [ PubMed ]

186. ALLISTON, T. and DERYNCK, R. (2002)  Interfering with bone remodeling (News and Views).  Nature 416, 686-687. [ PubMed]

185. QING, J. and DERYNCK, R.  (2002)  TGF-beta signaling and Cancer.  In The Cancer Handbook (M. Alison, Ed.)  Nature Publishing Group, Macmillan Publishers Ltd, 179-194.

184. ROBERTS, A.B. and DERYNCK, R.  (2001)  Meeting Report: Signaling Schemes for TGF-beta. Science STKE. 113pe43. [ PubMed ]

183. LIU, D., BLACK, B.L., and DERYNCK, R.  (2001)  TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Genes Dev. 15, 2950-2966. [ PubMedCentral to PDF ]

182. AKHURST, R.J. and DERYNCK, R.  (2001)  TGF-beta signaling in cancer:  a two-edged sword.  Trends Cell Biol. 11, S44-S51. [ PubMed ]

181. DERYNCK, R., AKHURST,  R.J., AND BALMAIN, A.  (2001) TGF-beta signaling in tumor suppression and cancer progression.  Nature Genetics 29, 117-129  (Erratum Nature Genetics 29, 351) [ PubMed ]

180. STOLL, S.W., KANSRA, S., PESCHIK, S., FRY, D.W., LEOPOLD, W.R., WIESEN, J.F., SIBILIA, M., ZHANG, T., WERB, Z., DERYNCK, R., WAGNER, E.F., and ELDER, J.T.  (2001)  Differential utilization and localization of ErbB receptor tyrosine kinases in skin compared to normal and malignant keratinocytes. Neoplasia 3, 339-350. [ PubMedCentral to PDF ]

179. ALLISTON, T., CHOY, L., DUCY, P., KARSENTY, G., and DERYNCK, R.  (2001) TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation.  EMBO J.20, 2254-2272. [ PubMedCentral to PDF ]

178. FENG, X.-H., and DERYNCK, R.  (2001)  Mammalian two-hybrid assays:  analyzing protein-protein interactions in the TGF-beta signaling pathway.  In Two-hybrid systems: Methods and Protocols (ed. P. McDonald) (series:  Methods in Molecular Biology, vol. 177)  Humana Press. pp 221-239. [ PubMed ]

177. ZHANG, Y., CHANG, C., GEHLING, D.J., HEMMATI-BRIVANLOU, A., and DERYNCK, R.  (2001) Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. Proc. Natl. Acad. Sci.USA, 98, 974-979. [ PubMedCentral to PDF ]

176. QING, J., ZHANG, Y. and DERYNCK, R.  (2000)  Structural and functional characterization of the TGF-beta-induced Smad3/c-Jun transcriptional cooperativity. J. Biol. Chem. 275, 38802-38812. [ PubMed ]

175. PATIL, S., WILDEY, G.M., BROWN, T.L., CHOY, L., DERYNCK, R., and HOWE, P.H.  (2000)  Smad7 is induced by CD40 and protects WEHI-231 B lymphocytes from TGF-beta-induced growth inhibition and apoptosis. J. Biol. Chem. 275, 38363-38370. [ PubMed ]

174. KUO, A., ZHONG, C., LANE, W.S. and DERYNCK, R.  (2000) Transmembrane transforming growth factor-alpha tethers to the PDZ-domain containing, Golgi-membrane-associated protein p59/GRASP55.  EMBO J. 19, 6427-6439. [ PubMedCentral to PDF ]

173. FENG, X.-H., LIN, X., and DERYNCK, R.  (2000)  Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B expression in response to TGF-beta. EMBO J. 19, 5178-5193. [ PubMedCentral to PDF ]

172. ZHANG, Y. and DERYNCK, R (2000) Transcriptional regulation of the TGF-beta-inducible, mouse germ-line Igalpha constant region gene by functional cooperation of Smad, CREB and AML family members.  J. Biol. Chem.275, 16979-16985. [ PubMed ]

171. CHOY, L., SKILLINGTON, J. and DERYNCK, R.  (2000)  Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation.  J. Cell. Biol. 149, 667-681. [ PubMedCentral to PDF ]

170. ALLISTON, T.N. and DERYNCK, R.  (2000)  Transforming growth factor-beta in skeletal development and maintenance.  In Skeletal Growth Factors (ed. E. Canalis), Lippincott Williams and Wilkins, Philadelphia, p. 233-249.

169. SHI, W., FAN, H., SHUM, L., and DERYNCK, R.  (2000)  The tetraspanin CD9 associates with transmembrane TGF-alpha and regulates TGF-alpha-induced EGF receptor activation and cell proliferation.  J. Cell Biol., 148, 591-601. [ PubMedCentral to PDF ]

168. DERYNCK, R.  (1999)  Skeletal development in the zebrafish.  Nature Genetics 23, 379.  [ PubMed ]

167. FAN, H. and DERYNCK, R.  (1999)  Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades.  EMBO J.  18, 6962-6972. [ PubMedCentral to PDF ]

166. FILVAROFF, E., ERLEBACHER, A., YE, J.-Q., GITELMAN, S.E., LOTZ, J., HEILLMAN, M., and DERYNCK, R.  (1999) Inhibition of TGF-beta receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass.  Development, 126, 4267-4279. [ PubMed ]

165. KORNBLUM, H. I., ZURCHER, S.D., WERB, Z., DERYNCK, R., and SEROOGY, K. (1999)  Multiple trophic actions of heparin-binding epidermal growth factor (HB-EGF) in the central nervous system.  Eur. J. Neurosci., 11, 3236-3246. [ PubMed ]

164. ZHANG, Y. and DERYNCK, R.  (1999)  Regulation of Smad signaling by protein associations and signaling crosstalk.  Trends Cell Biol. 9, 274-279. [ PubMed ]

163. MIETTINEN, P.J., CHIN, J.R., SHUM, L., SLAVKIN, H.C., SHULER, C.F., DERYNCK, R., and WERB, Z.  (1999)  EGF receptor function is necessary for normal craniofacial development and palate closure.  Nature Genetics 22, 69-73. [ PubMed ]

162. DERYNCK, R., ZHANG, Y., and FENG, X.-H.  (1998) Smads: transcriptional activators of TGF-beta responses. Cell 95, 737-740. [ PubMed ]

161. CHOY, L., and DERYNCK, R.  (1998)  The type II transforming growth factor-beta (TGF-beta) receptor-associated protein TRIP-1 acts as a modulator of the TGF-beta response.  J. Biol. Chem. 273, 31455-31462. [ PubMed ]

160. GRISWOLD-PRENNER, I., KAMIBAYASHI, C., MARUOKA, E.M., MUMBY, M.C., and DERYNCK, R.  (1998)  Physical and functional interactions between type I transforming growth factor-beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A.  Molec. Cell. Biol. 18, 6595-6604. [ PubMedCentral to PDF ]

159. FILVAROFF, E. and DERYNCK, R.  (1998)  Bone remodeling:  A signalling system for osteoclast regulation.  Current Biology 8, R679-R682. [ PubMed ]

158. SEBASTIAN, J., RICHARDS, R.G., WALKER, M.P., WIESEN, J.F., WERB, Z., DERYNCK, R., HOM, Y.K., CUNHA, G.R., and DIAUGUSTINE, R.P.  (1998)  Activation and function of the epidermal growth factor receptor and erbB-2 during mammary gland morphogenesis.  Cell Growth and Diferentiation 9, 777-785. [ PubMed ]

157. KORNBLUM, H.I., HUSSAIN, R., WIESEN, J., MIETTINEN, P., ZURCHER, S.D., CHOW, K., DERYNCK, R. and WERB, Z.  (1998)  Abnormal astrocyte development and neuronal death in mice lacking the epidermal growth factor receptor.  J. Neurosci. Res. 53, 697-717. [ PubMed ]

156. ZHANG, Y., FENG, X.-H., and DERYNCK, R.  (1998)  Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription.  Nature 394, 909-913.  (Erratum: Nature 396, 491) [ PubMed ]

155. DERYNCK, R. and CHOY, L.  (1998)  Transforming growth factor-beta and its receptors.  In The Cytokine Handbook (A. Thompson, ed.)  Academic Press, Boston, San Diego, 3rd edition, pp. 593-636.

154. FENG, X.-H., ZHANG, Y., WU, R.-Y., and DERYNCK, R.  (1998)  The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-beta-induced transcriptional activation. Genes Dev. 12, 2153-2163. [ PubMedCentral to PDF ]

153. ERLEBACHER, A., FILVAROFF, E.H., YE, J.-Q., and DERYNCK, R.  (1998)  Osteoblastic responses to TGF-beta during bone remodeling.  Molec. Biol. Cell 9, 1903-1918. [ PubMedCentral to PDF ]

152. DERYNCK, R.  (1998)  SMAD proteins and mammalian anatomy.  (News and Views)  Nature 393, 737-739. [ PubMed ]

151. GORSKA, A.E., JOSEPH, H., DERYNCK, R., MOSES, H.L., and SERRA, R.  (1998)  Dominant-negative interference of the TGF-beta type II receptor in the mammary gland results in alveolar hyperplasia and differentiation in virgin mice.  Cell Growth and Differentiation 9, 229-238. [ PubMed ]

150. HOM. Y.K., YOUNG, P., WIESEN, J., MIETTINEN, P.J., DERYNCK, R., WERB, Z., and CUNHA, G.  (1998)  Uterine and vaginal organ growth requires epidermal growth factor receptor (EGFR) signaling from stroma. Endocrinology 139, 913-921. [ PubMed ]

149. VERLHAC, M.-H., CHEN, R.-H., HANACHI, P., HERSHEY, J.W.B., and DERYNCK, R.  (1997)  Identification of partners of TIF34, a component of the yeast eIF3 complex, required for cell proliferation and translation initiation.  EMBO J. 16, 6812-6822. [ PubMedCentral to PDF ]

148. SERRA, R., JOHNSON, M., FILVAROFF, E.H., LABORDE, J., SHEHAN, D., DERYNCK, R., and MOSES, H.L.  (1997)  Expression of a cytoplasmically truncated TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and an osteoarthritis-like phenotype.  J. Cell Biol. 139, 541-552.  [ PubMedCentral to PDF ]

147. CANDIA, A., WATABE, T., HAWLEY, S.H.B., ONICHTCHOUCK, D., ZHANG, Y., DERYNCK, R., NIEHRS, C., and CHO, K.  (1997)  Cellular interpretation of multiple TGF-beta signals:  intracellular antagonism of activin/BVg1 and BMP-2/4 signaling mediated by Smads.  Development 124, 4467-4480. [ PubMed ]

146. DERYNCK, R. and FENG, X.-H.  (1997)  TGF-beta receptor signaling.  BBA Reviews in Cancer 1333, F105-F150. [ PubMed ]

145. MIETTINEN, P.J., WARBURTON, D., BU, D., ZHAO, J.-S., BERGER, J.E., MINOO, P., ALLEN, L., DOBBS, L., WERB, Z., and DERYNCK, R.  (1997)  Impaired lung branching morphogenesis in the absence of functional EGF receptor.  Dev. Biol. 186, 224-236. [ PubMed ]

144. FENG, X.-H., and DERYNCK, R.  (1997)  A kinase subdomain of the transforming growth factor-beta (TGF-beta) type I receptor determines the TGF-beta intracellular signaling specificity.  EMBO J. 16, 3912-3923. [ PubMedCentral to PDF ]

143. LAWLER, S., FENG, X.-H., CHEN, R.-H., MARUOKA, E.M., TURCK, C.W., GRISWOLD-PRENNER, I., and DERYNCK, R.  (1997)  The type II transforming growth factor-beta receptor autophosphorylates not only on serine and threonine but also on tyrosine residues.  J. Biol. Chem. 272, 14850-14859. [ PubMed ]

142. WU, R.-Y., ZHANG, Y., FENG, X.-H., and DERYNCK, R.  (1997)  Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4.  Molec. Cell. Biol. 17, 2521-2528. [ PubMedCentral to PDF ]

141. ZHANG, Y., MUSCI, T., and DERYNCK, R.  (1997)  The tumor suppressor Smad 4/DPC 4 as a central mediator of Smad function.  Current Biology 7, 270-276. [ PubMed ]

140. WANG, X.-J., GREENHALGH, D.A., BICKENBACH, J.R., JIANG, A., BUNDMAN, D.S., KRIEG, T., DERYNCK, R., and ROOP, D.R.  (1997)  Expression of a dominant negative type II transforming growth factor-beta receptor in the epidermis of transgenic mice blocks TGF-beta-mediated growth inhibition.  Proc. Natl. Acad. Sci. USA 94, 2386-2391.  [ PubMedCentral to PDF ]

139. GITELMAN, S.E., KOBRIN, M., LEE, A., FET, V., LYONS, K., HOGAN, B.L.M., and DERYNCK, R.  (1997)  Structure and sequence of the mouse Bmp6 gene.  Mammalian Genome 8, 212-214. [ PubMed ]

138. SHUM, L., TURCK, C.W., and DERYNCK, R.  (1996)  Cysteines 153 and 154 of transmembrane transforming growth factor-alpha are palmitoylated and mediate cytoplasmic protein association.  J. Biol. Chem. 271, 28502-28508. [ PubMed ]

137. DERYNCK, R., GELBART, W.M., HARLAND, R.M., HELDIN, C.-H., KERN, S.E., MASSAGUE, J., MELTON, D.A., MLODZIK, M., PADGETT, R.W., ROBERTS, A.B., SMITH, J., THOMSEN, G.H., VOGELSTEIN, B., and WANG, X.-F.  (1996)  Nomenclature:  vertebrate mediators of TGF-beta family signals (note).  Cell 87, 173. [ PubMed ]

136. DERYNCK, R. and ZHANG, Y.  (1996)  Intracellular signaling: The Mad way to do it.  Current Biology 6, 1226-1229.  [ PubMed ]

135. FILVAROFF, E.H., and DERYNCK, R.  (1996)  Induction of myogenesis in mesenchymal cells by MyoD depends on their degree of differentiation.  Dev. Biol. 178, 459-469. [ PubMed ]

134. ZHANG, Y., FENG, X.-H., WU, R.-Y., and DERYNCK, R.  (1996)  Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.  Nature 382, 168-172. [ PubMed ]

133. FENG, X-H, and DERYNCK, R.  (1996)  Ligand-independent activation of transforming growth factor-beta signaling pathways by heteromeric cytoplasmic domains of TGF-beta receptors.  J. Biol. Chem. 271, 13123-13129. [ PubMed ]

132. SHUM, L., MIETTINEN, P.J., and DERYNCK, R.  (1996)  Transforming growth factor-alpha.  In Human Cytokines: Handbook for Basic and Clinical Research, Vol. II (B. B. Aggarwal and J. U. Gutterman, eds.) Blackwell Scientific Publications, 384-421.

131. ERLEBACHER, A. and DERYNCK, R.  (1996)  Increased expression of TGF-beta2 in osteoblasts results in an osteoporosis-like phenotype.  J. Cell Biol. 132, 195-210. [ PubMedCentral to PDF ]

130. ARRICK, B.A., and DERYNCK, R.  (1996)  The biological role of transforming growth factor-beta in cancer development.  In Molecular Endocrinology of Cancer (J. Waxman, editor).  Cambridge University Press, p. 51-78.

129. DERYNCK, R., and WAGNER, E.F.  (1995)  Cell differentiation:  Editorial overview.  Curr. Opin. Cell Biol. 7:  Differentiation (R. DERYNCK, and E.F. WAGNER, eds.), 843-844. [ PubMed ]

128. FENG, X.-H., FILVAROFF, E.H., and DERYNCK, R.  (1995)  Transforming growth factor-beta-induced downregulation of cyclin A expression requires a functional TGF-beta receptor complex:  Characterization of chimeric and truncated type I and type II receptors.  J. Biol. Chem. 270, 24237-24245. [ PubMed ]

127. CHEN, R.-H., MIETTINEN, P.J., MARUOKA, E.M., CHOY, L. and DERYNCK, R.  (1995)  A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor.  Nature 377, 548-552. [ PubMed ]

126. MIETTINEN, P.J., BERGER, J.E., MENESES, J., PHUNG, Y., PEDERSEN, R.A., WERB, Z., and DERYNCK, R.  (1995)  Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor.  Nature376, 337-341. [ PubMed ]

125. GITELMAN, S.E., KIRK, M., YE, J.-Q., FILVAROFF, E.H., KAHN, A., and DERYNCK, R.  (1995)  Vgr-1/BMP-6 induces osteoblastic differentiation of pluripotent mesenchymal cells.  Cell Growth and Differentiation 6, 827-836.[ PubMed ]

124. CHEN, R.-H., MOSES, H.L., MARUOKA, E.M., DERYNCK, R., and KAWABATA, M.  (1995)  Phosphorylation-dependent interaction of the cytoplasmic domains of the type I and type II transforming growth factor-beta receptors.  J. Biol. Chem. 270, 12235-12241. [ PubMed ]

123. ERLEBACHER, A., FILVAROFF, E.H., GITELMAN, S.E., and DERYNCK, R.  (1995)  Toward a molecular understanding of skeletal development.  Cell 80, 371-378. [ PubMed ]

122. GITELMAN, S.E., and DERYNCK, R.  (1995)  Transforming growth factor-beta.  In Guidebook to Cytokines and their Receptors (N.A. Nicola, ed.) Oxford University Press, 223-226.

121. KHERADMAND, F., FOLKESSON, H.G., SHUM, L., DERYNCK, R.,  PYTELA, R., and MATTHAY, M.A.   (1994)  Transforming growth factor-alpha enhances alveolar epithelial cell repair in a new in vitro model.  Am. J. Physiol. 267 (Lung Cell. Mol. Physiol. 11), L728-L738. [ PubMed ]

120. DERYNCK, R., CHEN, R.-H., EBNER, R., FILVAROFF, E.H., and LAWLER, S.  (1994) An emerging complexity of receptors for transforming growth factor-beta. In Proceedings of the 24th International Symposium of the Princess Takamatsu Cancer Research Fund:  Molecular and cellular basis for cell to cell interaction:  its significance in cancer (Hirohashi, S., Moses, H.L., Ruoslahti, E., Sugimura, T., Takeichi, M., and Terada, M., eds) Princeton Scientific Publishing Co, 264-275. [ PubMed ]

119. MIETTINEN, P.J., EBNER, R., LOPEZ, A.R., and DERYNCK, R.  (1994)  TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells:  involvement of type I receptors.  J. Cell Biol. 127, 2021-2037. [ PubMedCentral to PDF ]

118. DERYNCK, R.  (1994)  TGF-beta receptor-mediated signaling.  Trends Biochem. Sci. 19, 548-553. [ PubMed]

117. GITELMAN, S.E., KORBIN, M.S., YE, J.-Q, LOPEZ, A.R., LEE, A., and DERYNCK, R.  (1994)  Recombinant vgr-1/BMP-6 expressing tumors induce fibrosis and endochondral bone formation in vivo.  J. Cell Biol. 126, 1595-1610. [ PubMedCentral to PDF ]

116. CHEN, R.-H. and DERYNCK, R.  (1994)  Homomeric interactions between type II transforming growth factor-beta receptors.  J. Biol. Chem. 269, 22868-22874. [ PubMed ]

115. DERYNCK, R.  (1994)  Transforming growth factor-beta.  In The Cytokine Handbook (A. Thomson, ed.)  Academic Press, Boston, San Diego, 2nd edition, 319-342.

114. FILVAROFF, E. H., EBNER, R., and DERYNCK, R.  (1994)  Inhibition of myogenic differentiation in myoblasts expressing a truncated type II TGF-beta receptor.  Development 121, 185-195.  [ PubMed ]

113. SHUM, L., REEVES, S.A., KUO, A.C., FROMER, E.S., and DERYNCK, R.  (1994)  Association of the transmembrane TGF-alpha precursor with a protein kinase complex.  J. Cell Biol. 125, 903-916. [ PubMedCentral to PDF ]

112. BARECELLOS-HOFF, M.-H., DERYNCK, R., TSANG, M.L.-S., and WEATHERBEE, J.A.  (1994)  Transforming growth factor-beta activation in irradiated murine mammary gland.  J. Clin. Invest. 93, 892-899. [ PubMedCentral to PDF ]

111. LAWLER, S., CANDIA, A.F., EBNER, R., LOPEZ, A.R., MOSES, H.L., WRIGHT, C.V.E., and DERYNCK, R.  (1994)  The murine type II TGF-beta receptor has a coincident embryonic expression and binding preference for TGF-beta1.  Development 120, 165-175. [ PubMed ]

110. NABEL, E.G., SHUM, L., POMPILI, V.J., YANG, Z.Y., SAN, H., SHU, H.B., LIPTAY, S., GOLD, L., GORDON, R., DERYNCK, R., and NABEL, G.J.  (1993)  Direct transfer of transforming growth factor beta1 gene into arteries stimulates fibrocellular hyperplasia.  Proc. Natl. Acad. Sci. USA 90, 10759-10763. [ PubMedCentral to PDF ]

109. EBNER, R., CHEN, R.-H, LAWLER, S., ZIONCHECK, T., and DERYNCK, R.  (1993)  Determination of type I receptor ligand specificity by the type II receptors for TGF-beta or activin.  Science 262, 900-902. [ PubMed ]

108. CHANG, H.-L., GILLETT, N., FIGARI, I., LOPEZ, A.R., PALLADINO, M.A., and DERYNCK, R.  (1993)  Increased transforming growth factor-beta expression inhibits cell proliferation in vitro, yet increases tumorigenicity and tumor growth of Meth A sarcoma cells. Cancer Res. 53, 4391-4398. [ PubMed ]

107. PITTELKOW, M.R., COOK, P.W., SHIPLEY, G.D., DERYNCK, R., and COFFEY, R.J., Jr.  (1993)  Autonomous growth of human keratinocytes requires epidermal growth factor receptor occupancy. Cell Growth and Differerentiation 4, 513-521. [ PubMed ]

106. EBNER, R., CHEN, R.-H., SHUM, L., LAWLER, S., ZIONCHECK, T., LOPEZ, A.R., and DERYNCK, R.  (1993)  Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor.  Science260, 1344-1348. [ PubMed ]

105. CHEN, R.-H., EBNER, R. and DERYNCK, R.  (1993)  Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-beta activities.  Science 260, 1335-1338. [ PubMed ]

104. GAZIT, D., EBNER, R., KAHN, A.J., and DERYNCK, R.  (1993)  Modulation of expression and cell surface binding of members of the transforming growth factor-beta superfamily during retinoic acid-induced osteoblastic differentiation of multipotential mesenchymal cells.  Molec. Endocrinol. 7, 189-198. [ PubMed ]

103. ARRICK, B.A., and DERYNCK, R.  (1993)  Growth regulation by transforming growth factor-beta.  In Oncogenes and Tumor Suppressor Genes in Human Malignancies (C. Benz and E. Liu, eds.) Kluwer Academic Publishers, 255-264.

102. STREULI, C.H., SCHMIDHAUSER, C., KOBRIN, M., BISSELL, M.J., and DERYNCK, R.  (1993)  Extracellular matrix regulates expression of the TGF-beta1 gene.  J. Cell Biol. 120, 253-260. [ PubMedCentral to PDF ]

101. ARRICK, B.A.,  LOPEZ, A.R.,  ELFMAN, F.,  EBNER, R.,  DAMSKY, C.H.,  DERYNCK, R.  (1992)  Altered metabolic and adhesive properties and increased tumorigenesis associated with increased expression of transforming growth factor-beta1.  J. Cell Biol. 118, 715-726. [ PubMedCentral to PDF ]

100. LOPEZ, A.R., COOK, J., DEININGER, P.L., and DERYNCK, R.  (1992)  Dominant negative mutants of transforming growth factor-beta1 inhibit the secretion of different transforming growth factor-beta isoforms. Molec. Cell. Biol. 12, 1674-1679. [ PubMedCentral to PDF ]

99. DERYNCK, R.  (1992)  The physiology of transforming growth factor-alpha.  Adv. Cancer Res. 58, 27-52. [ PubMed ]

98. LYONS, R.M., MILLER, D.A., GRAYCAR, J.L., MOSES, H.L,  and DERYNCK, R.  (1991)  Differential binding of TGF-beta1, -beta2 and -beta3 by fibroblasts and epithelial cells measured by affinity cross-linking of cell surface receptors.  Molec. Endocrin. 5, 1887- 1896. [ PubMed ]

97. ARRICK, B.A., LEE, A., GRENDELL, R.L., and DERYNCK, R.  (1991)  Inhibition of translation of transforming growth factor-beta3 mRNA by its 5' untranslated region.  Mol. Cell. Biol. 11, 4306-4313. [ PubMedCentral to PDF]

96. EBNER, R., and DERYNCK, R.  (1991)  Epidermal growth factor and transforming growth factor-alpha:  differential intracellular routing and processing of ligand-receptor complexes. Cell Regulation 2,  599-612. [ PubMedCentral to PDF ]

95. BALENTIEN, E., MUSSON, B.E., SHATTUCK, R.L., DERYNCK, R., and RICHMOND, A.  (1991)  Effects of MGSA 1/gro alpha on melanocyte transformation.  Oncogene 6, 1115-1124. [ PubMed ]

94. THOMAS, H.G., HAN, J.H., BALENTIEN, E., DERYNCK, R., BORDONI, R., and RICHMOND, A.  (1991)  Purification and characterization of recombinant melanoma growth stimulating activity.  Meth. Enzymol. 198 C, 373-383. [ PubMed ]

93. LUCAS, C., BRINGMAN, T. S., and DERYNCK, R.  (1991)  Generation of antibodies and assays for transforming growth factor-alpha. Meth. Enzymol. 198 C, 185-191. [ PubMed ]

92. DERYNCK, R.  (1991)  Transforming growth factor-beta.  In  Encyclopedia of Human Biology (R. Dulbecco, ed.) vol 7, 631-638.

91. DERYNCK, R.  (1991)  Transforming growth factor-alpha.  In  Encyclopedia of Human Biology (R. Dulbecco, ed.),vol. 7, 625-629.

90. BALENTIEN, E., HAN, J. H., THOMAS, H. G., WEN, D., SAMANTHA, A. K., ZACHARIAE, C. O., GRIFFIN, P., BRACHMANN, R., WONG, W. L., MATSUSHIMA, K., RICHMOND, A., and DERYNCK, R.  (1990)  Recombinant expression, biochemical characterization and biological activities of the human MGSA/gro protein.  Biochemistry29, 10225-10233. [ PubMed ]

89. DING, A., NATHAN, C., GRAYCAR, J., DERYNCK, R., STUEHR, D. J., and SRIMAL, S.  (1990)  Macrophage deactivating factor and transforming growth factors-beta1, -beta2, and -beta3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma.  J. Immunol. 145, 940-944. [ PubMed ]

88. DERYNCK, R.  (1990)  Transforming growth factor-alpha. Molec. Reprod. Devel. 27, 3-9. [ PubMed ]

87. MILLER, D. A., PELTON, R. W., DERYNCK, R., and MOSES, H. L.  (1990)  Transforming growth factor-beta:  a family of growth regulatory peptides.  In  Annals of the New York Academy of Sciences Vol. 593:  Transforming Growth Factor-betas.  Chemistry, Biology and Therapeutics (K.A Piez and M.B. Sporn), 208-217. [ PubMed ]

86. DICKINSON, M.E., KOBRIN, M. S., SILAN, C.M., KINGSLEY, D.M., JUSTICE, M. J., MILLER, D. A., CECI, J. D., LOCK, L. F., LEE, A., BUCHBERG, A. M., SIRACUSA, L. D., LYONS, K. M., DERYNCK, R., HOGAN, B. L. M., COPELAND, N. G., and JENKINS, N. A.  (1990)  Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci.  Genomics 6, 505-520. [ PubMed ]

85. ARRICK, B.A., KORC, M., and DERYNCK, R.  (1990)  Differential regulation of expression of three different transforming growth factor-beta species in human breast cancer cell lines by estradiol.  Cancer Res. 50, 299-303. [ PubMed ]

84. LYONS, K.M., PELTON, R.W., GRAYCAR, J.L., DERYNCK, R., and HOGAN, B.L.M.  (1990)  Developmental expression of the murine Vgr-1 gene: a new member of the TGF-beta multigene family.  In Current communications in molecular biology:  molecular genetics of early Drosophila and mouse development (M. Capecchi, ed.) (Cold Spring Harbor Laboratories), 109-116.

83. GRAYCAR, J. L., MILLER, D.A., ARRICK, B.A., LYONS, R.M., MOSES, H.L., and DERYNCK, R.  (1989)  Human transforming growth factor beta3: recombinant expression, purification and biological activities in comparison with transforming growth factors -beta1 and -beta2. Molec. Endocrin. 3, 1977-1986. [ PubMed ]

82. MILLER, D.A., LEE, A., MATSUI, Y., CHEN, E.Y., MOSES , H.L., and DERYNCK, R.  (1989)  Complementary DNA cloning of the murine transforming growth factor-beta3 precursor and the comparative expression of TGF-beta3 and TGF-beta1 mRNA in murine embryos and adult tissues.  Molec. Endocrin. 3, 1926-1934. [ PubMed ]

81. BASCOM, C.C., WOLFSHOHL, J.R., COFFEY, R.J., MADISEN, L., WEBB,N.R., PURCHIO, A.R., DERYNCK, R., and MOSES, H.L.  (1989)  Complex regulation of transforming growth factor beta1, beta2 and beta3 mRNA expression in mouse fibroblasts and keratinocytes by transforming growth factor beta1 and beta2.  Mol. Cell. Biol.9, 5508-5515. [ PubMedCentral to PDF ]

80. MILLER, D.A., LEE, A., PELTON, R.W., CHEN, E.Y., MOSES, H.L., and DERYNCK, R.  (1989)  Murine transforming growth factor-beta2 cDNA sequence and expression in adult tissues and embryos.  Molec. Endocrin.3, 1108-1114. [ PubMed ]

79. WEN, D., ROWLAND, A., and DERYNCK, R.  (1989)  Expression and secretion of gro/MGSA by stimulated human endothelial cells.  EMBO J. 8, 1761-1766. [ PubMedCentral to PDF ]

78. DERYNCK, R.  Transforming growth factors-alpha and-beta and their potential roles in neoplastic transformation.  (1989)  Cancer Treatment and Research Vol 47:  Oncogenes (C. Benz and E. Liu, eds.) Kluwer Academic Publishers, 177-195. [ PubMed ]

77. LYONS, K., GRAYCAR,J.L., LINDQUIST, P.B., LEE, A., CHEN, E. Y., HOGAN, B., and DERYNCK, R.  (1989)  Vgr-1, a mammalian gene related to Xenopus  vg-1, is a member of the transforming growth factor-beta gene superfamily. Proc. Natl. Acad. Sci. USA 86, 4554-4558. [ PubMedCentral to PDF ]

76. DERYNCK, R., LINDQUIST, P.B., BRINGMAN, T.S., WILCOX, J.N., ELDER, J.T., FISHER, G.L., VOORHEES, J.J., MOSES, H.L., PITTELKOW, M., and COFFEY, R.J.  (1989)  Expression of the transforming growth factor-alpha gene in tumor cells and normal cells.  Cancer Cells Vol. 7 (Cold Spring Harbor Laboratory), 297-301.

75. SHANKAR, V., CIARDIELLO, F., KIM, N., DERYNCK, R., LISCIA, D.S., MERLO, G., LANGTON, B.C., SHEER, D., CALLAHAN, R., BASSIN, R.H., LIPPMAN, M.E., HYNES, N., and SALOMON, D.S.  (1989)  Transformation of an established mouse mammary epithelial cell line following transfection with a human transforming growth factor-alpha cDNA.  Molecular Carcinogenesis 2, 1-11. [ PubMed ]

74. PITTELKOW, M.R., LINDQUIST, P.B., ABRAHAM, R., GRAVES-DEAL, R., DERYNCK, R. , and COFFEY, R.J.  (1989)  Induction of transforming growth factor-alpha expression in human keratinocytes by phorbol esters.  J. Biol. Chem. 264, 5164-5171. [ PubMed ]

73. BRACHMANN, R., LINDQUIST, P.B., NAGASHIMA, M., KOHR,W., LIPARI, T., NAPIER, M., and DERYNCK, R.  (1989)  Transmembrane TGF-alpha precursors activate EGF/TGF-alpha receptors. Cell 56, 691-700. [ PubMed ]

72. OQUENDO, P., ALBERTA, J., WEN, D., GRAYCAR, J.L., DERYNCK, R., and STILES, C.D.  (1989)  The platelet derived growth factor-inducible KC gene encodes a secretory protein related to platelet alpha-granule proteins.  J. Biol. Chem. 264, 4133-4137. [ PubMed ]

71. ELDER, J.T., FISHER, G.J., LINDQUIST, P.B., BENNETT, G.L., PITTELKOW, M., COFFEY, R.J., ELLINGSWORTH, L., DERYNCK, R., and VOORHEES, J.J.  (1989)  Overexpression of transforming growth factor-alpha in psoriatic skin.  Science 243, 811-814. [ PubMed ]

70. DERYNCK, R., LINDQUIST, P.B., TAMM, J., WEN, D., GRAYCAR, J., LEE, A., and CHEN,  E.Y.  (1988)  Transforming growth factor-beta: a family of structurally related factors.  Progress in Endocrinology 1988 (eds. H. Imura, K. Shizume, and S. Yoshida), Vol.1, 509-516.

69. BARTON, D.E., FOELLMER, B.E., DU, J., TAMM, J., DERYNCK, R., and FRANCKE, U.  (1988)  Chromosomal mapping of genes for transforming growth factors beta2 and beta3 in man and mouse:  dispersion of the TGF-beta gene family.  Oncogene Res. 3, 323-332. [ PubMed ]

68. JAKOBOVITS, E.B., SCHLOKAT, U., VANNICE, J.L., DERYNCK, R., and LEVINSON, A.D.  (1988)  The human TGF-alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence.  Mol. Cell. Biol. 8, 5549-5554. [ PubMedCentral to PDF ]

67. DERYNCK, R., LINDQUIST, P.B., LEE., A., WEN, D., TAMM, J., GRAYCAR, J.L., RHEE, L., MASON, A.J., MILLER, D.A., COFFEY, R.J., MOSES, H.L., and CHEN, E.Y.   (1988)  A new type of transforming growth factor-beta , TGF-beta3.  EMBO J. 7, 3737-3743. [ PubMedCentral to PDF ]

66. DERYNCK, R.  (1988)  Transforming growth factor-alpha. Cell 54, 593-595. [ PubMed ]

65. FINZI, E., KILKENNY, A., STRICKLAND, J.E., BALASCHAK, M., BRINGMAN, T.S., DERYNCK, R., AARONSON, S., and YUSPA, S.H.  (1988)  TGF-alphastimulates growth of skin papillomas by autocrine and paracrine mechanisms but does not cause neoplastic progression.  Molecular Carcinogenesis 1, 7-12. [ PubMed ]

64. RICHMOND, A., BALENTIEN, E., THOMAS H.G., FLAGGS, G., BARTON, D.E., SPIESS, J., BORDONI, R., FRANCKE, U.,  and DERYNCK, R.  (1988)  Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin.  EMBO J. 7, 2025-2033. [ PubMedCentral to PDF ]

63. WILCOX, J.N., and DERYNCK, R.  (1988)  Developmental expression of transforming growth factor-alpha and -beta in mouse fetus.  Mol. Cell. Biol. 8, 3415-3422. [ PubMedCentral to PDF ]

62. DERYNCK, R.  (1988)   Expression of transforming growth factor-alpha in tumor cells, in Progress in Cancer Research and Therapy Vol. 35; Hormones and Cancer 3 (ed. F. Bresciani, R.J.B. King, M.E. Lippman and J.P. Raymond) Raven Press, New York, p. 183-188.

61. DERYNCK, R.  (1988)  Transforming growth factor-alpha:  structure and biological activities.  In Growth Factors, Tumor Promoters and Cancer Genes, (Colburn, N.H., Moses, H.L., and Stanbridge, E.J. eds) Alan Liss, Inc. p1-12.

60. WILCOX, J.N., and DERYNCK, R.  (1988)  Localization of cells synthesizing transforming growth factor-alpha mRNA in the mouse brain.  J. Neurosci. 8, 1901-1904. [ PubMed ]

59. LIU, S.C., SANFILIPPO, B., PERROTEAU, I., DERYNCK, R., SALOMON, D.S., and KIDWELL, W.R.  (1987)  Expression of transforming growth factor-alpha (TGF-alpha) in differentiated rat mammary tumors: estrogen induction of TGF-alpha production.  Molec. Endocrin. 1, 683 -692. [ PubMed ]

58. GUTIERREZ, G., MUNDY, G.R., DERYNCK, R., HEWLETT, E.L., and KATZ, M.S.  (1987)  Inihibition of parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by transforming growth factor-alpha and epidermal growth factor.  J. Biol. Chem. 262, 15845-15850. [ PubMed ]

57. SMITH, J.J., DERYNCK, R., and KORC, M.  (1987)  Production of transforming growth factor-alpha in human pancreatic cancer cells: evidence for a superagonist autocrine cycle.  Proc. Natl. Acad. Sci. USA 84, 7567-7570. [ PubMedCentral to PDF ]

56. COFFEY, R.J., DERYNCK, R., WILCOX, J.N., BRINGMAN, T.S., GOUSTIN, A.S., MOSES, H.L., and PITTELKOW, M.R.  (1987)  Production and auto-induction of transforming growth factor-alpha in human keratinocytes.  Nature 328, 817-820. [ PubMed ]

55. DERYNCK, R., WINKLER, M.E., and SCHREIBER, A.B.  (1987)  Transforming growth  factor-alpha induces angiogenesis.  In Angiogenesis: mechanisms and pathobiology (Rifkin, D.B. and Klagsbrun, N., eds) p. 72-77.

54. DERYNCK, R., and RHEE, L.  (1987)  Sequence of the porcine transforming growth  factor-beta precursor.  Nucl. Acids Res. 15, 3187. [ PubMedCentral to PDF ]

53. DERYNCK, R., RHEE, L., CHEN, E.Y., and VAN TILBURG, A.  (1987)  Intron-exon structure of the human transforming growth factor-beta precursor gene.  Nucl. Acids Res. 15, 3188-3189. [ PubMedCentral to PDF ]

52. GAN, B.S., HOLLENBERG, M.D., MacCANNELL, K.L., LEDERIS, K., WINKLER, M.E., and DERYNCK, R.  (1987)  Distinct vascular actions of epidermal growth factor-urogastrone and transforming growth factor-alpha.  J. Pharm. Exp. Ther. 242, 331-337. [ PubMed ]

51. FINZI, E., FLEMING, T., SEGATTO, O., PENNIGTON, C., BRINGMAN, T.S., DERYNCK, R., and AARONSON, S.A.  (1987)  The human transforming growth factor-alpha coding sequence is not a direct acting oncogene when overexpressed in NIH/3T3 cells.  Proc. Natl. Acad. Sci. USA 84, 3733-3737. [ PubMedCentral to PDF ]

50. BRINGMAN, T.S., LINDQUIST, P.B., and DERYNCK, R.  (1987)  Different transforming growth factor-alpha species are derived from a glycosylated and palmitoylated transmembrane precursor.  Cell 48, 429-440. [ PubMed]

49. KNABBE, C., LIPPMAN, M.E., WAKEFIELD, L.E., FLANDERS, K.L., KASID, A., DERYNCK, R., and DICKSON, R.B.  (1987)  Evidence that transforming growth factor-beta is a hormonally regulated negative growth factor in human breast cancer cells.  Cell 48, 417-428. [ PubMed ]

48. DERYNCK, R., GOEDDEL, D.V., ULLRICH, A., GUTTERMAN, J.U., WILLIAMS, R.D., BRINGMAN, T.S., and BERGER, W.H.  (1987)  Synthesis of messenger RNAs for transforming growth factors-alpha and -betaand the epidermal growth factor receptor by human tumors.  Cancer Res. 47, 707-712. [ PubMed ]

47. SALOMON, D.S., PERROTEAU, I., KIDWELL, W.R., TAM, J.,  and DERYNCK, R.   (1987)  Loss of growth responsiveness to epidermal growth factor and enhanced production of alpha-transforming growth factor in ras-transformed mouse mammary epithelial cells.  J. Cell. Physiol. 130, 297-409. [ PubMed ]

46. DERYNCK, R.  (1987)  Structure of transforming growth factors-alpha and -beta and their precursors. In Oncogenes, genes and growth factors, (G. Guroff, ed.), 133-163.

45. DERYNCK, R.  (1986)  Transforming growth factor-alpha: structure and biological activities.  J. Cell. Biochem.32, 293-304. [ PubMed ]

44. DERYNCK, R., ROSENTHAL, A., LINDQUIST, P.B., BRINGMAN, T.S.,  and GOEDDEL, D.V.   (1986)  Endogenous and heterologous expression of transforming growth factor-alpha in mammalian cells.  Cold Spring Harbor Symp. Quant. Biol. 51, 649-655. [ PubMed ]

43. ROSENTHAL, A., LINDQUIST, P.B., BRINGMAN, T.S., GOEDDEL, D.V.,  and DERYNCK, R.  (1986)  Expression in rat fibroblasts of a human transforming growth factor-alpha cDNA results in transformation.  Cell 46, 301-309. [ PubMed ]

42. HAEGEMAN, G., CONTENT, J., VOLCKAERT, G., DERYNCK, R., TAVERNIER, J., and FIERS, W.  (1986)  Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts.  Eur. J. Biochem.159, 625-632. [ PubMed ]

41. TASHJIAN, A.H., VOELKEL, E.F., LLOYD, W., DERYNCK, R., WINKLER, M.E.,  and LEVINE, L.  (1986)  Actions of growth factors on plasma calcium: epidermal growth factor and human transforming growth factor-alpha cause elevation of plasma calcium in mice.  J. Clin. Invest. 78, 1405-1409. [ PubMedCentral to PDF ]

40. DERYNCK, R.  (1986)  Transforming growth factor-alpha.  In Oncogenes and Growth Control (T. Graf and P. Kahn, eds.), p. 58-64.

39. TAKAHASHI, N., McDONALD, B.R., HON, J., WINKLER, M.E., DERYNCK, R., MUNDY, G.R., and ROODMAN, G.D.  (1986)  Recombinant human transforming growth factor-alpha stimulates the formation of osteoclast-like cells in long-term human marrow cultures.  J. Clin. Invest. 78, 894-898. [ PubMedCentral to PDF ]

38. FUJII, D., BRISSENDEN, J.E., DERYNCK, R., and FRANCKE, U.  (1986)  Transforming growth factor-beta gene maps to human chromosome 19 long arm and to mouse chromosome 7.  Somatic Cell and Molecular Genetics 12, 281-288. [ PubMed ]

37. SCHREIBER, A.B., WINKLER, M.E., and DERYNCK, R.  (1986)  Transforming growth factor-alpha: a more potent angiogenic mediator than epidermal growth factor.  Science 232, 1250-1253. [ PubMed ]

36. KEHRL, J.H., WAKEFIELD, L.M., ROBERTS, A.B., JAKOWLEW, S., ALVAREZ-MON, M., DERYNCK, R., SPORN, M.B., and FAUCI, A.S.  (1986)  Production of transforming growth factor-beta by human T lymphocytes and its potential role in the regulation of T cell growth.  J. Exp. Med. 163, 1037-1050. [ PubMedCentral to PDF ]

35. DERYNCK, R., JARRETT, J.A., CHEN, E.Y., and GOEDDEL, D.V.  (1986)  The murine transforming growth factor-beta precursor.  J. Biol. Chem. 261, 4377-4379. [ PubMed ]

34. IBBOTSON, K.J., HARROD, J., GOWEN, M., D'SOUZA, S., WINKLER, M.E., DERYNCK, R., and MUNDY, G.R.  (1986)  Human recombinant transforming growth factor-alpha stimulates bone resorption and inhibits formation in vitro.  Proc. Natl. Acad. Sci. USA 83, 2228-2232. [ PubMedCentral to PDF ]

33. STERN, P.H., KRIEGER, N.S., NISSENSON, R.A., WILLIAMS, R.D., WINKLER, M.E. DERYNCK, R., and STREWLER, G.J.  (1985)  Human transforming growth factor-alpha stimulates bone resorption in vitro.  J. Clin. Invest. 76, 2016-2019. [ PubMedCentral to PDF ]

32. DERYNCK, R., JARRETT, J.A., CHEN, E.Y., EATON, D.H., BELL, J.R., ASSOIAN, R.K., ROBERTS, A.B., SPORN, M.B.,  and GOEDDEL, D.V.  (1985)  Human transforming growth factor-beta cDNA sequence and expression in normal and transformed cell lines.  Nature 316, 701-705. [ PubMed ]

31. BRISSENDEN, J.E., DERYNCK, R., and FRANCKE, U.  (1985)  Mapping of transforming growth factor-alpha gene to human chromosome 2 close to the breakpoint of the Burkitt lymphoma t(2:8) variant translocation. Cancer Res. 45, 5593-5597. [ PubMed ]

30. TASHJIAN, A.H., JR., VOELKEL, E.F., LAZZARO, M., SINGER, F.R., ROBERTS, A.B., DERYNCK, R., WINKLER, M.E.,  and LEVINE, L.  (1985)  Human transforming growth factors-alpha and -beta stimulate prostaglandin production and bone resorption in cultured mouse calvariae.  Proc. Natl. Acad. Sci. USA 82, 4535-4538. [ PubMedCentral to PDF ]

29. SMITH, J.M., SPORN, M.B., ROBERTS, A.B., DERYNCK, R., WINKLER, M.E., and  GREGORY, H.  (1985)  Human transforming growth factor-alpha causes precocious eyelid opening in newborn mice.  Nature 315, 515-516. [ PubMed ]

28. DERYNCK, R., ROBERTS, A.B., EATON, D.H., WINKLER, M.E.,  and GOEDDEL, D.V.  (1985)  Human transforming growth factor-alpha:  precursor sequence, gene structure and heterologous expression.  In Cancer Cells, vol. 3, 79-86, Cold Spring Harbor Laboratories.

27. PENNICA, D., NEDWIN, G.E., HAYFLICK, J.S., SEEBURG, P.H., DERYNCK, R., PALLADINO, M.A., KOHR, W.J., AGGARWAL, B.B., and GOEDDEL, D.V.  (1984)  Human tumor necrosis factor:  precursor structure, expression and homology to lymphotoxin.  Nature 312, 724-729. [ PubMed ]

26. DERYNCK, R., ROBERTS, A.B., WINKLER, M.E., CHEN, E.Y., and GOEDDEL, D.V.  (1984)  Human transforming growth factor-alpha:  precursor structure and expression in E. coli.  Cell 38, 287-297. [ PubMed ]

25. DERYNCK, R.  (1983)  More about interferon cloning.  Interferon 5 (I. Gresser, ed.) Academic Press p. 181-203. [ PubMed ]

24. DERYNCK, R.  (1983)  Genetic engineering and recombinant techniques for the production of interferon.  Proceedings of the 13th International Congress of Chemotherapy, Vienna (Austria) August 28 - September 2, Symposium Interferon, p. 202/4-202/13.

23. CONTENT, J., and DERYNCK, R.  (1983)  Les interférons en morceaux.  La Recherche 14, 232-235.

22. DERYNCK, R., SINGH, A., and GOEDDEL, D.V.  (1983)  Expression of the human interferon-gamma cDNA in yeast.  Nucl. Acids Res. 11, 1819-1837. [ PubMedCentral to PDF ]

21. DERYNCK, R., HITZEMAN, R.A., GRAY, P.W., and GOEDDEL, D.V.  (1983)  Expression of human interferon-gamma  in heterologous systems.  In Experimental Manipulation of Gene Expression (M. Inouye, ed.) Academic Press, 247-258.

20. REMAUT, E., DERYNCK, R., DEVOS, R., CHEROUTRE, H., CONTENT, J., CONTRERAS, R., DEGRAVE, W., GHEYSEN, D., STANSSENS, P., TAVERNIER, J., TAYA, Y., VAN HEUVERSWYN, H., and FIERS, W.  (1982)  Expression of human fibroblast and human immune interferon genes in homologous  and heterologous cells.  In Interaction of Translational and Transcriptional Controls in the regulation of Gene Expression (M. Grunberg-Manago and B. Safer, eds.) Elsevier Scientific Publishing Company, p. 435-446.

19. FIERS, W., DEGRAVE, W., DERYNCK, R., DEVOS, R., GHEYSEN, D., REMAUT,E.,  STANSSENS, P., TAVERNIER, J., CONTENT, J., and DE CLERCQ, E.  (1982)  The human fibroblast interferon gene(s) and their expression in heterologous cells.  In Primary and Tertiary Structure of Nucleic Acids and Cancer Research (M. Miwa et al., eds.) Japan Sci. Soc. Press, Tokyo, p. 227-236.

18. FIERS, W., DEGRAVE, W., DERYNCK, R., DEVOS, R., GHEYSEN, D., REMAUT, E., STANSSENS, P., TAVERNIER, J., CONTENT, J., and DERYNCK, R.  (1982)  The human interferon gene(s) and their expression in heterologous cells.  Princess Takamatsu Symposia 12, 227-236. [ PubMed ]

17. HITZEMAN, R.A., HAGIE, F.E., HAYFLICK, J.S., CHEN, C.Y., SEEBURG, P.H., and DERYNCK, R.  (1982)  The primary structure of the Saccharomyces cerevisiae  gene for 3-phosphoglycerate kinase.  Nucl. Acids Res. 10, 7791-7808. [ PubMedCentral to PDF ]

16. DERYNCK, R., LEUNG, D.W., GRAY, P.W., and GOEDDEL, D.V.  (1982)  Human interferon gamma is encoded by a single class of mRNA. Nucl. Acids Res. 10, 3605-3615. [ PubMedCentral to PDF ]

15. CONTENT, J., DE WIT, L., DERYNCK, R., DE CLERCQ, E., and FIERS, W   (1982)  In vitro  cotranslational processing of human pre-interferon beta1 enhances its biological activity.  Virology 122, 466-470. [ PubMed ]

14. SIMONSEN, C.C., SHEPARD, H.M., GRAY, P.W., LEUNG, D.W., PENNICA, D., YELVERTON, E., DERYNCK, R., SHERWOOD, P.J., LEVINSON, A.D., and GOEDDEL, D.V.  (1982)  Plasmid-directed synthesis of human immune interferon in E. coli  and monkey cells. In The Interferons (eds. T.C. Merigan, R.M. Friedman, and C.F. Fox), Academic Press, Proceedings of the UCLA Symposia on Molecular Biology, XXV, p. 1-14.

13. DERYNCK, R., GRAY, P.W., YELVERTON, E., LEUNG, D.W., SHEPARD, H.M., LAWN, R.M., ULLRICH, A., NAJARIAN, R., PENNICA, D., HAGIE, F.E., HITZEMAN, .A.,SHERWOOD, P.J., LEVINSON, A.D., and GOEDDEL, D.V.  (1982)  Synthesis of human interferons and analogs in heterologous cells.  In From Gene to Protein:  Translation into Biotechnology (Ahmed, F., Schultz, J., Smith, E.E. and Whelan, W.J., eds.)  Academic Press, New York, p. 249-259.

12. CONTENT, J., DE WIT, L., PIERARD, D., DERYNCK, R., DE CLERCQ, E., and FIERS, W.  (1982)  Secretory proteins induced in human fibroblasts under conditions used for the production of interferon beta (IFN-beta). Proc. Natl. Acad. Sci. USA 79, 2768-2772. [ PubMedCentral to PDF ]

11. GRAY, P.W., LEUNG, D.W., PENNICA, D., YELVERTON, E., NAJARIAN,  R., SIMONSEN, C.C., DERYNCK, R., SHERWOOD, P.J., WALLACE, D.M., BERGER, S.L., LEVINSON, A.D.,  and GOEDDEL, D.V.  (1982)  Expression of human immune interferon in E. coli  and monkey cells. Nature 295, 503-508. [ PubMed ]

10. VOLCKAERT, G., TAVERNIER, J., DERYNCK, R., DEVOS, R.,  and FIERS, W.  (1981)  Molecular mechanisms to explain nucleotide sequence rearrangements observed in  cDNA clones of human fibroblast interferon mRNA.  Gene 15, 215-223. [ PubMed ]

9. DERYNCK, R., DEGRAVE, W., GHEYSEN, D., HAEGEMAN, G., TAVERNIER, J., REMAUT, E., STANSSENS, P., SAMAN, E., LEEMANS, R.,  and FIERS, W.  (1981)  Studies of the human fibroblast interferon gene cloned inEscherichia coli.  In The Biology of the Interferon System, eds. De Maeyer, E., Galasso, G. en Schellekens, H., p. 57-62.

8. DERYNCK, R.  (1981)  Het menselijk interferon gen. Chemie Magazine Jrg. 7, nr. 1.

7. DEGRAVE, W., DERYNCK, R., TAVERNIER, J., HAEGEMAN, G., and FIERS, W.  (1981)  Nucleotide sequence of the chromosomal gene for human fibroblast (beta1) interferon and of the flanking regions.  Gene 14, 137-143. [ PubMed ]

6. TAVERNIER, J., DERYNCK, R.,  and FIERS, W.  (1981)  Evidence for a unique human fibroblast  interferon (IFN-beta1) chromosomal gene, devoid of intervening  sequences.  Nucl. Acids Res. 9, 461-471. [ PubMedCentral to PDF ]

5. DERYNCK, R., DEVOS, R., REMAUT, E., SAMAN, E., STANSSENS, P., TAVERNIER, J., VOLCKAERT, G., CONTENT, J., DE CLERCQ, E.,  and FIERS, W.  (1981)  Isolation and characterization of a human fibroblast interferon gene and its expression in Escherichia coli.  Reviews in Infectious Diseases, ed. A.S. Huang,  vol. 3, 1186-1195. [ PubMed ]

4. DERYNCK, R., REMAUT, E., SAMAN, E., STANSSENS, P., DECLERCQ, E., CONTENT, J.,  and FIERS, W.  (1980)  Expression of human fibroblast interferon gene in Escherichia coli.  Nature 287, 193-197. [ PubMed ]

3. DERYNCK, R., CONTENT, J., DECLERCQ, E., VOLCKAERT, G., TAVERNIER, J., DEVOS, R.,  and FIERS, W.  (1980)  Isolation and structure of a human fibroblast interferon gene. Nature 285, 542-547. [ PubMed ]

2. DERYNCK, R., and FIERS, W.  (1977)  Two-dimensional electrophoretic separation of restriction fragments.  Arch. Internat. Physiol. Biochim. 85, 167-168. [ PubMed ]

1. DERYNCK, R., and FIERS, W.  (1977)  A two-dimensional electrophoretic procedure for the separation of restriction fragments.  J. Mol. Biol. 110, 387-404. [ PubMed ]